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Learn about our mission, leadership, history, and partner institutions. Following postdoctoral research in the lab of Lily Jan at the University of California, San Francisco, Sheng served as a faculty member in the Department of Neurobiology at Massachusetts General Hospital and Harvard Medical School (1994-2001) before joining MIT (2001-2008). Dr. Fei Chen, a current Broad fellow and co-inventor of expansion microscopy, is building a lab at the Broad Institute that is focused on developing methods for studying differences in genome structure and mRNA expression. This researcher will work in close collaboration with laboratory scientists on analysis of a range of projects with a strong emphasis on bulk RNA-seq and single cell approaches. yuansf@hku.hk. We join with institutions and scientists the world over to address foundational challenges in science and health. Dr. Sheng has also servedon the editorial board of Journal of Cell Biology (JCB) and Journal of Biological Chemistry (JBC) and associate editor of Autophagy. About. Dr. Shengreceived the2021 Dr. Francisco S. Sy Award for Excellence in Mentorship at HHS. Zizhang Sheng is an associated research scientist in the Honig-Shapiro labs. Work with wet-lab biologists to design and implement appropriate experiments for future computational analysis in areas such as neurophysiology and behavior. . The Slim Center aims to bring the benefits of genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region. Gladstone is dedicated to mentoring tomorrow's leaders and equipping our trainees with a broad set of skills, so they can effect change to improve our world. Sheng and coworkers made important discoveries regarding the molecular mechanisms of synapse weakening and loss, the contributions of microglia and innate immunity in neurodegenerative diseases, and the roles of genetic risk factors in the pathogenesis of Alzheimers disease, Parkinsons disease, ALS, and frontotemporal dementia. However, research on the predictive potential and clinical importance of mitophagy-related genes (MRGs) in hepatocellular carcinoma (HCC) is currently lacking. Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research. Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broads Stanley Center for Psychiatric Research. Cambridge, MA 02142. We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap). A physician and a scientist, Morgan Sheng is author of more than 200 peer-reviewed publications focused on the molecular cellular biology of synapses and synaptic plasticity, and pathogenic mechanisms of neurodegenerative diseases. We are seeking a motivated Computational Associate II (CA) to join the Sheng Lab at the Broad Institute of MIT and Harvard. Compositions and Methods for Conversion of Aldehydes to Alkanes (2011) Weiqing Zeng and Sheng Yang He. Find our contact information, directions to our buildings, and directory. Software Engineer. Is this useful? Copyright 2008-2023, Glassdoor, Inc. "Glassdoor" and logo are registered trademarks of Glassdoor, Inc, The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of the. As Co-Director of the Stanley Center for Psychiatric Research at the Broad Institute, Sheng will help to shape the centers scientific vision and direction, and oversee the centers efforts to develop therapeutics for schizophrenia and other serious mental illnesses. (1st class honors) from Oxford University and obtained his medical degree and training at London University. The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression. We are a team of scientists studying the genetic basis and molecular mechanisms underlying schizophrenia and other brain disorders. Affiliations 1 State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. Many of their ongoing projects are multidisciplinary, bridging engineering with materials science, chemistry, and life sciences. Sheng Lin-Gibson (Fed) Dr. Sheng Lin-Gibson is the Chief of the Biosystems and Biomaterials Division (BBD) at the National Institute of Standards and Technology (NIST). Meet our members, staff scientists, fellows and other Broadies. In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity. From 2001 to 2008, Sheng was the Menicon Professor of Neuroscience at MIT, as well as an investigator of the Howard Hughes Medical Institute. The Sheng lab is a highly collegial and collaborative environment consisting of postdocs and graduate students who have the freedom to pursue a broad range of projects in the areas. Mark Inman, MBA COO and Administrator . This position in the Stanley Center for Psychiatric Research involves bioinformatics analysis in areas such as transcriptomics, neurophysiology, and behavior. Yun-Sheng Chen is an assistant professor at the University of Illinois, Urbana-Champaign. Affiliated Research Lab Inner Ear Electrophysiology Laboratory; Academic profile. The Stanley Center engages in large-scale, globally conducted studies of . . Here, we report a single-molecule approach capable of . Mobile Homes For Sale In Snyder County, Pa. $160,000.00. In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks. 2012 - 2017 Ershela Durresi, Ph.D. Medical Student, Harvard Medical School . Using genetic mouse models, his group is addressing several fundamental questions: (1) how mitochondrial transport is regulated to sense changes in synaptic activity, mitochondrial integrity, axon injury and pathological stress; (2) how neurons coordinate late endocytic transport and autophagy-lysosomal function to maintain cellular homeostasis and distal degradation capacity; (3) how impaired transport contributes to synaptic dysfunction and axonal pathology in neurodegenerative diseases. The successful candidate will join a multidisciplinary group and perform cutting-edge basic and/or translational research on the molecular, cellular and neurobiological mechanisms of psychiatric disorders, especially in relation to risk genes for schizophrenia and bipolar disorder, synapse development/elimination, synaptic function/plasticity, neuron-glia interactions, and neural circuitry/interneurons. Correlating atomic configurationsspecifically, degree of disorder (DOD)of an amorphous solid with properties is a long-standing riddle in materials science and condensed matter physics . The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of the Stanley Center for Psychiatric Research, The mission of the Stanley Center is to improve the lives of patients suffering from serious mental . Cambridge, MA. Postdoctoral Fellow, Laboratory of Steven McCarroll, Harvard Medical School and Broad Institute of MIT and Harvard. He joined NINDS as an investigator in 1997 and is now a tenured senior investigator and Chief of Synaptic Functions Section at National Institute of Neurological Disorders and Stroke (NINDS), NIH. Broad-spectrum disease resistance conferred by expression of the Pseudomonas syringae hrmA gene in plants (2001) Qingshun Li, Songhai Shen, Arthur Hunt and Sheng Yang He. In this paper, the effects of ultrasound frequency (17-25 kHz), power . He has served on the editorial boards of Neuron, Journal of Neuroscience, and Current Opinions in Neurobiology. Website. The Xpert HIV-1 qualitative assay (Xpert HIV-1 Qual; Cepheid, Sunnyvale, CA, USA) for early infant diagnosis is considered to be a point-of-care test according to the REASSURED criteria; 9 although it takes 90 min, the assay is able to provide results on the same day as testing. 699 Bradley C. Paasch, Reza Sohrabi, Kinya Nomura & Sheng Yang He 700 701 . Published in NANO Letters, the study was led by Zhi Sheng and Deborah . Sheng spent the past 10 years at Genentech, a preeminent biotech company, as Vice-President of Neuroscience. - POSTED ON 12/18/2022 AVAILABLE BEFORE 5/17/2023. Discover remarkable stories of scientific progress, and explore the intersections of science, medicine, and society. Basic laboratory methods of molecular cell biology, imaging, and/or electrophysiology, Self-motivation and rigorousness in experimental research, Excellent communication skills (written and oral), Ability to work independently and interact cooperatively with others, Expertise in computational/bioinformatics approaches to biological problems, Experience of data-rich experimental techniques, such as single cell RNAseq, ATACseq, MS proteomics, functional genomic screens, high content imaging. Explore the connection between art and science and how we bring together artists and Broad scientists through our artist-in-residence program, gallery exhibitions, and ongoing public conversations. Postdoctoral Associate - Sheng Lab in The Broad Institute, Inc. Cambridge, MA. Mailing address: California Institute of Technology. Popular Locations. Requests for exemption for medical or sincerely held religious beliefs will be considered. Research (Aboobaker Lab.) My research will involve a combination of organic synthesis, microbiology, molecular biology, enzymology, and potential optimization of . Morgan Sheng, Ph.D. Vice President of Neuroscience, Genentech, Inc., San Francisco, CA. Access free classroom materials and more for STEM educators, parents, students, tutors, and others. Postdoctoral Associate - Sheng Lab. Posted: December 20, 2022. Please contact Prof. Sheng-Yang He (shengyang.he@duke.edu; hes@msu.edu). I am passionate about developing and maintaining tools that allow . Yun-Sheng received his master's degrees in materials science and engineering from . Neuroscience Professor Salary in Boston, MA Yearly Monthly Weekly Hourly $16,744 - $30,787 3% of jobs $30,788 - $44,831 4% of jobs $54,554 is the 25th percentile. Sheng Ding, PhD Senior Investigator, Gladstone Institutes . Chemical biology and therapeutics science, Genome regulation, cellular circuitry, and epigenomics, Merkin Institute for Transformative Technologies in Healthcare, Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Several pre-existing RSV lineages powered the 2022 surge, Blood stem cells are susceptible to ferroptosis, a type of cell death, Rare genetic variants can reveal much about disease biology, Researchers map brain cell changes in Alzheimers disease. In Situ Biology Join Us Contact The Chen Lab. Sheng's laboratory focuses on the mechanisms regulating axonal transport of mitochondria, endocytic organelles, and synaptic cargo and their impact on axonal homeostasis, synaptic function and neurodegeneration. A multimodal molecular cell-type atlas of the MOp. This study aimed to uncover and analyze the mitophagy-related diagnostic biomarkers in HCC using . $115,000.00, $130,000.00 688 Timothy Johnson and lab technician David Rhodes for assistance in gnotobiotic system . Virginia Tech Carilion Research Institute scientists have developed new imaging techniques to watch dangerous brain tumor cells respond to treatment in real time. Dr. Fei Chen, a current Broad fellow and co-inventor of expansion microscopy, is building a lab at the Broad Institute that is focused on developing methods for studying differences in genome structure and mRNA expression. He continues to collaborate with the lab as PhD student in the Stanford Genetics program. This candidate will collaborate with biologists and geneticists to perform various analysis including transcriptomics and proteomics analysis, pathway analysis and biological interpretations. Browse 59 BOSTON, MA AUTISM RESEARCH job ($35K-$108K) listings hiring now from companies with openings. Oana Ursu Status: Postdoc, Aviv Regev lab, Broad Institute Lab Affiliation: PhD, Genetics Dept., Co-advised by Mike Snyder Sept 2013 - Mar 2018 (HHMI International Fellow) Research focus: 3D genome organization, enhancer-gene linking, regulatory . As Co-Director of the Stanley Center for Psychiatric Research at the Broad Institute, Sheng will help to shape the center's scientific vision and direction, and oversee the center's efforts to develop therapeutics for schizophrenia and other serious mental illnesses. The Slim Center aims to bring the benefits of genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region. Medical Student, Virginia Tech Carilion School of Medicine '24 Institute of Sustainability for Chemicals, Energy and Environment (ISCE 2) Institute of High Performance Computing (IHPC) . Consistently, TCGA data analysis shows an inverse correlation between LSD1 expression and CD8 + T cell infiltration in various human cancers. He is also a professor of neuroscience in MITs Department of Brain and Cognitive Sciences, and an affiliate of both the McGovern Institute for Brain Research and the Picower Institute for Learning and Memory. Sheng and coworkers made important discoveries regarding the molecular mechanisms of synapse weakening and loss, the contributions of microglia and innate immunity in neurodegenerative diseases, and the roles of genetic risk factors in the pathogenesis of Alzheimers disease, Parkinsons disease, and frontotemporal dementia. Feng Laboratory McGovern Institute For Brain Research 43 Vassar Street, Office: 46-3133 Cambridge, Massachusetts 02139 Phone: (617) 715-4920 Website: fenglaboratory.org. In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity. A catalog of scientific papers published by our members and staff scientists. We are thrilled to have him join the Broad, where his expertise as a physician-scientist and drug-discoverer will help us make strides toward the understanding and treatment of psychiatric diseases.. Our community is deeply engaged in the local, national, and global effort to respond to COVID-19. M Sheng, S Smiga, A Bulfone, . BBD has a multidisciplinary technical portfolio that includes genomic measurements, synthetic biology, regenerative medicine and advanced therapies, biomaterials, diagnostics . Associate Investigator, Broad Institute of Harvard/MIT Investigator, HHMI. Fei Chen, Principal Investigator. We are a team of scientists studying the genetic basis and molecular mechanisms underlying schizophrenia and other brain disorders. Copyright 2008-2023, Glassdoor, Inc. "Glassdoor" and logo are registered trademarks of Glassdoor, Inc, Computational Associate II, Stanley Center for Psychiatric Research, Title: Computational Associate II, Stanley Center for Psychiatric Research. The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression. Institute Members are deeply engaged in the intellectual life of Broad and are responsible for setting its scientific direction. Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broad's Stanley Center for Psychiatric Research. A physician and a scientist, Morgan Shengis author of more than 200 peer-reviewed publications focused on the molecular cellular biology of synapses and synaptic plasticity, and pathogenic mechanisms of neurodegenerative diseases. 46-1303 Cambridge, MA 02139 . Broad Institute's Tweets. Queen's University.